Inhibition of SUMOylation enhances responses to irreversible electroporation in pancreatic cancer
نویسندگان
چکیده
منابع مشابه
Use of irreversible electroporation in unresectable pancreatic cancer.
Irreversible electroporation is a non-thermal injury ablative modality that has been in clinical use since 2008 in the treatment of locally advanced soft tissue tumors. It has been reported to be utilized intraoperatively, laparoscopically or percutaneously. The method of action of IRE relies on a high voltage (maximum 3,000 volts) small microsecond pulse lengths (70 to 90 microseconds) to indu...
متن کاملCase report: Irreversible electroporation for locally advanced pancreatic cancer
INTRODUCTION For patients with pancreatic adenocarcinoma who are not candidates for surgical resection, long-term survival is poor, even with currently available systemic and radiation therapy options. However, for those with locally advanced disease who do not have distant metastasis, locoregional control of the tumor has the potential to improve long-term outcomes. A newly developed technolog...
متن کاملIrreversible electroporation for the treatment of pancreatic neuroendocrine tumors
BACKGROUNDS/AIMS Resection or enucleation is currently the treatment of choice for small pancreatic neuroendocrine tumors (NETs). Irreversible electroporation is a novel ablative method that is used for locally advanced pancreatic adenocarcinoma, but little data exists for its use for pancreatic NETs. We report an early experience of IRE for early pancreatic NETs. METHODS Between April 2014 a...
متن کاملIrreversible electroporation of locally advanced pancreatic neck/body adenocarcinoma.
OBJECTIVE Irreversible electroporation (IRE) of locally advanced pancreatic adenocarcinoma of the neck has been used to palliate appropriate stage 3 pancreatic cancers without evidence of metastasis and who have undergone appropriate induction therapy. Currently there has not been a standardized reported technique for pancreatic mid-body tumors for patient selection and intra-operative techniqu...
متن کاملIrreversible electroporation in locally advanced pancreatic cancer: A call for standardization of energy delivery.
Irreversible Electroporation (IRE) is used to treat locally advanced cancers, commonly of the pancreas, liver, kidney, and other soft tissues. Precise eligibility for IRE should be established in each individual patient by a multidisciplinary team based on comprehensive clinical, imaging, and laboratory assessment. Standardization of IRE technique and protocols is expected to improve safety, le...
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ژورنال
عنوان ژورنال: British Journal of Surgery
سال: 2021
ISSN: 0007-1323,1365-2168
DOI: 10.1093/bjs/znab202.027